This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
TRIM21 Antibodies
AND TRIM21 ELISA kits, TRIM21 Proteins
Many biological assays use antibodies to detect TRIM21, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRIM21 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRIM21 antibodies...
Designing a Western blot for TRIM21? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TRIM21 Western Blot GuideDesigning an IHC experiment for TRIM21? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TRIM21 IHC GuideTRIM21 Infographic by Boster Bio
All TRIM21 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A02079-2
100 μg/vial
Cat # A02079-2
100 μg/vial
Human, Mouse, Rat
IF, ICC, WB
$370
Cat # A02083
100 μg/vial
Cat # A02083
100 μg/vial
TRIM21 Overview
Facts about E3 ubiquitin-protein ligase TRIM21.
E3 ubiquitin-protein ligase TRIM21 (TRIM21)
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Types a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that's used not only for the ubiquitination of USP4 and IKBKB but also because of its self-ubiquitination.
Part of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)- like complex is shown to mediate ubiquitination of CDKN1B ('Thr- 187' phosphorylated-form), thereby promoting its degradation by the proteasome.
Gene Information
| Human | |
|---|---|
| Gene Name: | TRIM21 |
| Uniprot: | P19474 |
| Entrez: | 6737 |
Family
| Belongs to: |
|---|
| TRIM/RBCC family |
Alternative Names
52 kDa ribonucleoprotein autoantigen Ro/SS-A; 52 kDa Ro/SSA; E3 ubiquitin-protein ligase TRIM21; EC 6.3.2.-; rhTRIM21; RNF81; RNF81RING finger protein 81; ro(SS-A); Ro52; RO52SS-A; Sicca syndrome antigen A; Sjoegren syndrome type A antigen; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro); SSA1; SSA1SSA; TRIM21; tripartite motif containing 21,52 kDa Ro protein; tripartite motif-containing 21; Tripartite motif-containing protein 21
Molecular Weight
Mass (kDA):
54.17 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.4 |
| Sequence: | 11; NC_000011.10 (4384897..4393702, complement) |
Tissue Specificity
Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung.
Subcellular Localizations
Cytoplasm. Cytoplasmic vesicle, autophagosome. Nucleus. Cytoplasm, P-body. Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called processing bodies (P-bodies) that are located underneath the plasma membrane and also diffusely in the cytoplasm. They are located along the microtubules and are highly motile in cells. Colocalizes with DCP2 in P-bodies.
Diseases
- Lupus Erythematosus, Systemic
- Autoimmune Reaction
- Autoimmune Diseases
- Sjogren's Syndrome
- Autoimmunity
- Virus Diseases
- Hiv Infections
- Immunologic Deficiency Syndromes
- Sclerosis
- Diffuse Scleroderma
- Inflammation
- Anemia
Interacting Proteins
- GRAP
- TRIM3
- TRIM39
- TXN2
- USP15
Pathways
- Cytokine Production
- Immune Response
- Pathogenesis
- Proteolysis
- Cell Proliferation
- Tolerance Induction
- Reverse Transcription
- Translation
- Cell Death
PTMs
- Ubiquitination
Research Areas
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRIM21
bosterbio.com/bosterbio-gene-info-cards/TRIM21
References
PMID: 1985094 by Itoh K., et al. Protein heterogeneity in the human Ro/SSA ribonucleoproteins. The 52- and 60-kD Ro/SSA autoantigens are encoded by separate genes.
PMID: 1985112 by Chan E.K., et al. Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen.
3 Publications of Boster TRIM21 Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.wneu.2016.05.063, High FABP5 Versus CRABPII Expression Ratio in Recurrent Craniopharyngiomas: Impl...
- PubMed ID: -, Min He,Si-Qi Zhao,Xi-Yan Guo et al.Effects of Terminalia chebula Retz. on the Se...
- PubMed ID: -, Chun Wang,Bin Wang,Maimaiti Aili,Shixia Huo,Meng-ting Han,Silafu Aibai,Zhi-Jian ...
*More publications can be found for each product on its corresponding product page