Activating signal cointegrator 1 (TRIP4)

Transcription coactivator which associates with nuclear receptors, transcriptional coactivators such as EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an significant role in establishing distinct coactivator complexes under different cellular conditions.

Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity).