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- Table of Contents
TRIP4 Antibodies
AND TRIP4 ELISA kits, TRIP4 Proteins
Many biological assays use antibodies to detect TRIP4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRIP4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRIP4 antibodies...
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TRIP4 Infographic by Boster Bio
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TRIP4 Overview
Facts about Activating signal cointegrator 1.
Activating signal cointegrator 1 (TRIP4)
Transcription coactivator which associates with nuclear receptors, transcriptional coactivators such as EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an significant role in establishing distinct coactivator complexes under different cellular conditions.
Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | TRIP4 |
| Uniprot: | Q15650 |
| Entrez: | 9325 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
activating signal cointegrator 1; ASC-1; HsT17391; thyroid hormone receptor interactor 4; thyroid receptor interacting protein 4; Thyroid receptor-interacting protein 4; TR-interacting protein 4; TRIP-4
Molecular Weight
Mass (kDA):
66.146 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q22.31 |
| Sequence: | 15; NC_000015.10 (64387836..64455303) |
Subcellular Localizations
Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic under conditions of serum deprivation (PubMed:10454579). Colocalizes with NEK6 in the centrosome (PubMed:20873783).
Diseases
- Adenocarcinoma
- Malignant Neoplasms
- Neoplasms
- Colonic Neoplasms
- Malignant Tumor Of Colon
- Stage I Colon Carcinoma
- Barrett Esophagus
Pathways
- Transport
- Translation
- D-serine Transport
- Localization
- Rna Interference
- Spermatogenesis
- Secretion
PTMs
- Acetylation
- Isopeptide bond
Research Areas
- Apoptosis
- Cancer
- DNA Repair
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRIP4
bosterbio.com/bosterbio-gene-info-cards/TRIP4
References
PMID: 10454579 by Kim H.J., et al. Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation.
PMID: 7776974 by Lee J.W., et al. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.