This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
TRPA1 Antibodies
AND TRPA1 ELISA kits, TRPA1 Proteins
Many biological assays use antibodies to detect TRPA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRPA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRPA1 antibodies...
Designing a Western blot for TRPA1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TRPA1 Western Blot GuideTRPA1 Infographic by Boster Bio
All TRPA1 Products
Product
Figures
Specificity
Applications
Price
TRPA1 Overview
Facts about Transient receptor potential cation channel subfamily A member 1.
Transient receptor potential cation channel subfamily A member 1 (TRPA1)
Receptor-activated non-selective cation channel involved in detection of pain and maybe also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central part in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as olive oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126).
Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312).
Gene Information
| Human | |
|---|---|
| Gene Name: | TRPA1 |
| Uniprot: | O75762 |
| Entrez: | 8989 |
Family
| Belongs to: |
|---|
| transient receptor (TC 1.A.4) family |
Alternative Names
ANKTM1ankyrin-like with transmembrane domains 1; Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120; transient receptor potential cation channel subfamily A member 1; transient receptor potential cation channel, subfamily A, member 1
Molecular Weight
Mass (kDA):
127.501 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q21.11 |
| Sequence: | 8; NC_000008.11 (72021250..72094885, complement) |
Tissue Specificity
Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Pain
- Inflammation
- Hyperalgesia
- Nervousness
- Neuralgia
- Neurogenic Inflammation
- Coughing
- Hyperalgesias, Mechanical
- Asthma
- Nerve Damage
- Chronic Pain
Pathways
- Hypersensitivity
- Sensitization
- Reflex
- Secretion
- Pathogenesis
- Synaptic Transmission
- Localization
- Innervation
- Transport
- Inflammatory Response
- Vasodilation
- Thermotaxis
- Phototransduction
PTMs
- Phosphorylation
- Oxidation
- Cleavage
- Biotinylation
- Nitrosylation
Research Areas
- Neuronal Cell Markers
- Neuroscience
- Neurotransmission
- Sensory Systems
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRPA1
bosterbio.com/bosterbio-gene-info-cards/TRPA1
References
PMID: 10066796 by Jaquemar D., et al. An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts.
PMID: 25389312 by Moparthi L., et al. Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain.