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- Table of Contents
Tetraspanin-12 Antibodies
AND TSPAN12 ELISA kits, Tetraspanin-12 Proteins
Many biological assays use antibodies to detect Tetraspanin-12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tetraspanin-12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tetraspanin-12 antibodies...
Designing an IHC experiment for Tetraspanin-12? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TSPAN12 IHC GuideTSPAN12 Infographic by Boster Bio
All TSPAN12 Products
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TSPAN12 Overview
Facts about Tetraspanin-12.
Tetraspanin-12 (TSPAN12)
Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and excite LEF/TCF-mediated transcriptional programs.
Suprisingly, it only trigger the norrin (NDP)-dependent activation of FZD4, while it does not trigger the Wnt-dependent activation of FZD4, suggesting the occurrence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP.
Gene Information
| Human | |
|---|---|
| Gene Name: | TSPAN12 |
| Uniprot: | O95859 |
| Entrez: | 23554 |
Family
| Belongs to: |
|---|
| tetraspanin (TM4SF) family |
Alternative Names
EVR5; Leukemia-associated protein with a CXXC domain; methylcytosine dioxygenase TET1; NET2; NET-2; ten-eleven translocation-1; tetraspanin-12; TM4SF12; TSPAN12
Molecular Weight
Mass (kDA):
35.383 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q31.31 |
| Sequence: | 7; NC_000007.14 (120787320..120858337, complement) |
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Retinal Diseases
- Proliferative Vitreoretinopathy
- Blind Vision
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Tumor Angiogenesis
- Retinal Neovascularization
- Retinal Detachment
- Retinopathy Of Prematurity
- Cell Invasion
- Malignant Neoplasm Of Breast
Interacting Proteins
- ADAM10
- TFCP2
Pathways
- Angiogenesis
- Proteolysis
- Cell Growth
- Cell Adhesion
- Cell Proliferation
- Blood Vessel Development
- Eye Development
- Pathogenesis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TSPAN12
bosterbio.com/bosterbio-gene-info-cards/TSPAN12
References
PMID: 10719184 by Serru V., et al. Sequence and expression of seven new tetraspans.
PMID: 19587294 by Xu D., et al. Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein.