Transcription termination factor 1 (TTF1)

Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and modulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription.

Interaction with BAZ2A/TIP5 recovers DNA-binding activity. .