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- Table of Contents
Titin Antibodies
AND TTN ELISA kits, Titin Proteins
Many biological assays use antibodies to detect Titin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Titin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Titin antibodies...
Designing an IHC experiment for Titin? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TTN IHC GuideTTN Infographic by Boster Bio
All TTN Products
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TTN Overview
Facts about Titin.
Titin (TTN)
Key component in the assembly and functioning of vertebrate striated muscles. By giving connections at the level of human microfilaments, it contributes to the fine balance of forces between the two parts of the sarcomere.
The size and extensibility of the cross-links are the chief determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | TTN |
| Uniprot: | Q8WZ42 |
| Entrez: | 7273 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
cardiomyopathy, dilated 1G (autosomal dominant); CMD1G; CMH9; CMPD4; connectin; DKFZp451N061; EC 2.7.11.1; EOMFC; FLJ32040; FLJ34413; FLJ39564; FLJ43066; HMERF; LGMD2JFLJ26020; MPRM; Rhabdomyosarcoma antigen MU-RMS-40.14; titin; TMDFLJ26409
Molecular Weight
Mass (kDA):
3816.03 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q31.2 |
| Sequence: | 2; NC_000002.12 (178525989..178807423, complement) |
Tissue Specificity
Isoforms 3, 7 and 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate skeletal muscle. Isoform 6 is expressed in skeletal muscle (at protein level).
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Tachypnea
- Transitory Tachypnea Of Newborn
- Cardiomyopathies
- Respiratory Distress
- Respiratory Distress Syndrome, Newborn
- Cardiomyopathy, Dilated
- Myopathy
- Hypertrophy
- Dystrophy
- Respiration Disorders
- Malignant Neoplasms
- Muscular Dystrophy
Interacting Proteins
- ACTN1
- ACTN2
- CAPN3
- DNAJB5
- DYSF
- ENO1
- MYBPC2
- MYBPH
- MYOM2
- NEB
Pathways
- Secretion
- Pathogenesis
- Regeneration
- Seed Development
- Localization
- Cell Proliferation
- Mitosis
- Cell Differentiation
- Transport
- Fertilization
- Phagocytosis
- Cell Cycle
- Aldosterone Secretion
PTMs
- Oxidation
- Phosphorylation
- Cleavage
Research Areas
- Cancer
- Cell Biology
- Cellular Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TTN
bosterbio.com/bosterbio-gene-info-cards/TTN
References
PMID: 7569978 by Labeit S., et al. Titins, giant proteins in charge of muscle ultrastructure and elasticity.
PMID: 10850961 by Freiburg A., et al. Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity.