TTI1 Antibodies

AND TTI1 ELISA kits, TTI1 Proteins

Many biological assays use antibodies to detect TTI1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TTI1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TTI1 antibodies...

We validate the specificity of these antibodies to TTI1 by testing them on tissues known to express TTI1 positively and negatively. Browse below to find the TTI1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TTI1 Infographic by Boster Bio

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TTI1 (NM_014657) Human Over-expression Lysate

Human

$628
Cat # LS009675
20 µg, 100 µg

TTI1 Overview

Facts about TELO2-interacting protein 1 homolog.

TTI1 3D structure. Source: alphafold

TELO2-interacting protein 1 homolog (TTI1)

Regulator of the DNA damage response (DDR). Part of this TTT complex that's required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins.

The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complicated and HSP90 may take part in the correct folding of newly synthesized PIKKs.

Gene Information

Human
Gene Name:	TTI1
Uniprot:	O43156
Entrez:	9675

Family

Belongs to:

tti1 family

Alternative Names

KIAA0406SMG10; Protein SMG10; Tel two interacting protein 1; Tel2 interacting protein 1 homolog (S. pombe); TEL2-interacting protein 1 homolog

Molecular Weight

Mass (kDA):
122.069 kDA

Genomic Context


Human

Location:	20q11.23
Sequence:	20; NC_000020.11 (37983014..38033461, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Cytoplasm.

Diseases

Instabilities, Chromosomal
Malignant Neoplasms
Neoplasms
Obesity
Nerve Degeneration
Ataxia
Retinopathy Of Prematurity

Diabetes Mellitus

Interacting Proteins

ATM
ATR
FBXO9
TELO2

Pathways

Cell Growth
Translation
Telomere Maintenance
Aging
Hypersensitivity
Localization

Autophagy

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TTI1

References

PMID: 20427287 by Kaizuka T., et al. Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

PMID: 20810650 by Hurov K.E., et al. A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.