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- Table of Contents
Facts about TELO2-interacting protein 2.
The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complicated and HSP90 may participate in the proper folding of newly synthesized PIKKs.
Human | |
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Gene Name: | TTI2 |
Uniprot: | Q6NXR4 |
Entrez: | 80185 |
Belongs to: |
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TTI2 family |
C8orf41; chromosome 8 open reading frame 41; FLJ23263; hypothetical protein LOC80185; TELO2 interacting protein 2; TTI2
Mass (kDA):
56.915 kDA
Human | |
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Location: | 8p12 |
Sequence: | 8; NC_000008.11 (33498722..33513135, complement) |
PMID: 20810650 by Hurov K.E., et al. A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.
PMID: 20801936 by Takai H., et al. Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.