Tubulin beta-2B chain Antibodies

AND Tubb2b ELISA kits, Tubulin beta-2B chain Proteins

Many biological assays use antibodies to detect Tubulin beta-2B chain, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tubulin beta-2B chain in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tubulin beta-2B chain antibodies...

We validate the specificity of these antibodies to Tubulin beta-2B chain by testing them on tissues known to express Tubb2b positively and negatively. Browse below to find the Tubb2b antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Tubulin beta-2B chain? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the TUBB2B IHC Guide

Tubb2b Infographic by Boster Bio

All Tubb2b Products

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Specificity

Applications

Price

Anti-TUBB2B Antibody (N-term)

Immunohistochemical analysis of paraffin-embedded Human brain tissue using A05849 performed on the Leica® BOND RXm

Human, Mouse, Rat

IF, WB, IHC-P-Leica

$299
Cat # A05849
80 µl

TUBB2B (NM_178012) Human Over-expression Lysate

Human

$628
Cat # LS347733
20 µg, 100 µg

Tubb2b Overview

Facts about Tubulin beta-2B chain.

Tubulin beta-2B chain (Tubb2b)

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Plays a crucial role in proper axon guidance in both peripheral and central axon tracts. Implicated in neuronal migration.

Gene Information

Mouse
Gene Name:	Tubb2b
Uniprot:	Q9CWF2
Entrez:	73710

Family

Belongs to:

tubulin family

Alternative Names

bA506K6.1; class II beta-tubulin isotype; DKFZp566F223; FLJ98847; MGC8685; tubulin beta-2B chain; tubulin, beta 2B; tubulin, beta polypeptide paralog

Molecular Weight

Mass (kDA):
49.953 kDA

Genomic Context


Mouse

Location:	13\|13 A3.3
Sequence:	13;

Tissue Specificity

Strong expression is detected in the developing cortex and peripheral nervous system, as well as in the adult cerebellum, hippocampus and olfactory bulb.

Diseases

Polymicrogyria
Lissencephaly
Malformations Of Cortical Development
Nervousness
Neuronal Migration Disorders
Nervous System Disorder
Fibrosis
Congenital Anomaly Of Brain
Pachygyria
Microcephaly
Ocular Motility Disorders
Hypoplasia
Malnutrition

Schizencephaly
Macular Corneal Dystrophy Type I
Malignant Neoplasms
Neoplasms
Microtubule Process
Osteoporosis
Ectopic Tissue

Pathways

Axon Guidance
System Development
Nervous System Development
Neurogenesis
Localization
Cell Division
Stem Cell Differentiation
Osteoblast Differentiation

Cell Cycle
Cell Differentiation
Heart Development

PTMs

Acetylation
Isopeptide bond

Methylation
Phosphoprotein

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Tubb2b

References

PMID: 15890843 by Janke C., et al. Tubulin polyglutamylase enzymes are members of the TTL domain protein family.

PMID: 19465910 by Jaglin X.H., et al. Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria.