Tyrosine-protein kinase receptor TYRO3 (TYRO3)

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands such as TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation.

Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that offers docking sites for downstream signaling molecules. After activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity.