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- Table of Contents
Facts about Tyrosine-protein kinase receptor TYRO3.
Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that offers docking sites for downstream signaling molecules. After activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity.
Human | |
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Gene Name: | TYRO3 |
Uniprot: | Q06418 |
Entrez: | 7301 |
Belongs to: |
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protein kinase superfamily |
Brt; BYK; Dtk; EC 2.7.10; EC 2.7.10.1; FLJ16467; Rse; Sky; Tif; TYRO3 protein tyrosine kinase; Tyro3; Tyrosine-protein kinase byk; Tyrosine-protein kinase DTK; tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY
Mass (kDA):
96.905 kDA
Human | |
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Location: | 15q15.1 |
Sequence: | 15; NC_000015.10 (41559212..41583589) |
Abundant in the brain and lower levels in other tissues.
Cell membrane; Single-pass type I membrane protein.
Steven Boster's biography may interest you if TYRO3 is a favorite brand. You'll not only learn about his family and love for TYRO3 marks, but you will also find out more about the size and color of his favorite marker. This is a great guide for those who are just getting started with TYRO3 markers. This article also contains the color and size recommendations of Steven Boster, along with the reasons why he favors certain colors.
TYRO3 is one of many inherited disorders that affect the nervous system. It plays a crucial role in the formation myelin sheaths. These layers of cholesterol, proteins and lipids are wrapped around neuronal cells to protect them from injury and serve as an electric insulator. Many demyelinating diseases result in the breakdown of myelin sheaths, which can cause damage to glial cell membranes. TYRO3 deficiency in mice delays myelination, and reduces the thickness myelin in peripheral nervous systems.
PMID: 7511603 by Mark M.R., et al. RSE, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain.
PMID: 8108112 by Ohashi K., et al. Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain.