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Product Info Summary
| SKU: | M00913-1 |
|---|---|
| Size: | 80 µl |
| Reactive Species: | Mouse |
| Host: | Mouse |
| Application: | WB |
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Product info
Product Name
Anti-Tyro3 Antibody
SKU/Catalog Number
M00913-1
Size
80 µl
Description
Boster Bio Anti-Tyro3 Antibody (Catalog # M00913-1). Tested in WB application(s). This antibody reacts with Mouse.
Storage & Handling
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Cite This Product
Anti-Tyro3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00913-1)
Host
Mouse
Contents
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Clonality
Monoclonal
Clone Number
1444CT895.86.31
Isotype
IgG1,k
Immunogen
This Tyro3 antibody is generated from a mouse immunized with a recombinant protein.
Reactive Species
M00913-1 is reactive to Tyro3 in Mouse
Calculated molecular weight
96.2 kDa
Background of Tyro3
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M00913-1 is guaranteed for WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:2000
Validation Images & Assay Conditions
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Western blot analysis of lysate from mouse brain tissue lysate, using Tyro3 Antibody. M00913-1 was diluted at 1:2000. A goat anti-mouse IgG H&L (HRP) at 1:3000 dilution was used as the secondary antibody. Lysate at 20μg.
Specific Publications For Anti-Tyro3 Antibody (M00913-1)
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