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- Table of Contents
1 Citations 7 Q&As
Facts about Teratocarcinoma-derived growth factor 1.
Shedding of TDGF1 by TMEM8A modulates Nodal signaling by enabling soluble TDGF1 to act as a Nodal coreceptor on other tissues (PubMed:27881714). Could play a role in the determination of the epiblastic cells which then give rise to the mesoderm (PubMed:11909953).
Human | |
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Gene Name: | TDGF1 |
Uniprot: | P13385 |
Entrez: | 6997 |
Belongs to: |
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EGF-CFC (Cripto-1/FRL1/Cryptic) family |
CFC-2; CR; Cripto; Cripto-1 growth factor; Cripto-1; CRIPTOCRGF; Epidermal growth factor-like cripto protein CR1; TDGF1; TDGF-1; teratocarcinoma-derived growth factor 1
Mass (kDA):
21.169 kDA
Human | |
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Location: | 3p21.31 |
Sequence: | 3; NC_000003.12 (46574535..46582457) |
Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Released from the cell membrane by GPI cleavage.
PMID: 2792079 by Ciccodicola A., et al. Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells.
PMID: 1882841 by Dono R., et al. Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence.
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