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Tfap2e Antibodies
AND Tfap2e ELISA kits, Tfap2e Proteins
Many biological assays use antibodies to detect Tfap2e, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tfap2e in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tfap2e antibodies...
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Tfap2e Overview
Facts about Transcription factor AP-2-epsilon.
Transcription factor AP-2-epsilon (Tfap2e)
Sequence-specific DNA-binding protein which interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development.
They also suppress several genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a part in the development of the CNS and in cartilage differentiation.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Tfap2e |
| Uniprot: | Q6VUP9 |
| Entrez: | 332937 |
Family
| Belongs to: |
|---|
| AP-2 family |
Alternative Names
Activating enhancer-binding protein 2-epsilon; adaptor-related protein complex 2, epsilon subunit; AP2 epsilon; AP-2 epsilon; AP2E; AP2-epsilon; MGC49007; TFAP2E; transcription factor AP-2 epsilon (activating enhancer binding protein 2epsilon); transcription factor AP-2-epsilon
Molecular Weight
Mass (kDA):
46.283 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 4|4 D2.2 |
| Sequence: | 4; |
Tissue Specificity
Expressed most prominently in the mitral cell layer of the developing olfactory bulb and to a lesser extent in the granule cell layer. Also expressed in skin, articular cartilage, primary chondrocytes, and chondrosarcoma cell line SW1353.
Diseases
- Malignant Neoplasms
- Colorectal Neoplasms
- Colorectal Cancer
- Malignant Neoplasm Of Prostate
- Cell Transformation, Neoplastic
- Adenoma
- Microphthalmos
- Melanoma
- Microsatellite Instability
Pathways
- Methylation
- Dna Methylation
- Drug Resistance
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Tfap2e
bosterbio.com/bosterbio-gene-info-cards/Tfap2e
References
PMID: 14636996 by Tummala R., et al. Molecular cloning and characterization of AP-2 epsilon, a fifth member of the AP-2 family.
PMID: 14572467 by Feng W., et al. Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb.