Toll-like receptor 13 (Tlr13)

Part of innate and adaptive immunity that recognizes and binds 23S rRNA from germs. TLRs (Toll-like receptors) control host immune response against pathogens through comprehension of molecular patterns unique to microorganisms.

Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory reaction. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a succession also jumped by MLS group antibiotics (including erythromycin).