Transmembrane protein 64 Antibodies

AND Tmem64 ELISA kits, Transmembrane protein 64 Proteins

Many biological assays use antibodies to detect Transmembrane protein 64, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transmembrane protein 64 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transmembrane protein 64 antibodies...

We validate the specificity of these antibodies to Transmembrane protein 64 by testing them on tissues known to express Tmem64 positively and negatively. Browse below to find the Tmem64 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Tmem64 Infographic by Boster Bio

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TMEM64 (NM_001146273) Human Over-expression Lysate

Human

$628
Cat # LS169200
20 µg, 100 µg

Tmem64 Overview

Facts about Transmembrane protein 64.

Transmembrane protein 64 (Tmem64)

Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways through its interaction with SERCA2 that's critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS production necessary for proper osteoclast generation.

Association between TMEM64 and SERCA2 in the ER contributes to cytosolic Ca (2+) spiking for activation of NFATC1 and generation of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (PubMed:23395171). Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway.

Gene Information

Mouse
Gene Name:	Tmem64
Uniprot:	Q3U145
Entrez:	100201

Family

Belongs to:

TVP38/TMEM64 family

Alternative Names

Transmembrane protein 64

Molecular Weight

Mass (kDA):
39.815 kDA

Genomic Context


Mouse

Location:	4\|4 A2
Sequence:	4;

Tissue Specificity

Liver, testis, kidney and muscle.

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Tmem64

References

PMID: 23395171 by Kim H., et al. Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation.

PMID: 25979161 by Jeong B.C., et al. Transmembrane protein 64 reciprocally regulates osteoblast and adipocyte differentiation by modulating Wnt/beta-catenin signaling.