This website uses cookies to ensure you get the best experience on our website.
- Table of Contents

Facts about Post-GPI attachment to proteins factor 6.
Has phospholipase A2 action that removes an acyl-chain in the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface.
| Mouse | |
|---|---|
| Gene Name: | Tmem8a |
| Uniprot: | Q9ESN3 |
| Entrez: | |

| Belongs to: |
|---|
| TMEM8 family |

five-span transmembrane protein M83; Protein M83; TMEM6; TMEM8; Transmembrane protein 6M83; transmembrane protein 8 (five membrane-spanning domains); Transmembrane protein 8; transmembrane protein 8A
Mass (kDA):
85.329 kDA

| Mouse | |
|---|---|
| Location: | |
| Sequence: | ; |


PMID: 11006113 by Motohashi T., et al. Molecular cloning and chromosomal mapping of a novel five-span transmembrane protein gene, M83.
PMID: 27881714 by Lee G.H., et al. A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO.