Tomt Antibodies

AND Tomt ELISA kits, Tomt Proteins

Many biological assays use antibodies to detect Tomt, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tomt in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tomt antibodies...

We validate the specificity of these antibodies to Tomt by testing them on tissues known to express Tomt positively and negatively. Browse below to find the Tomt antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Tomt Infographic by Boster Bio

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Tomt Overview

Facts about Transmembrane O-methyltransferase homolog.

Tomt 3D structure. Source: alphafold

Transmembrane O-methyltransferase homolog (Tomt)

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (PubMed:18794526). Required for auditory function (PubMed:18794526, PubMed:28504928).

Part of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complicated.

Gene Information

Mouse
Gene Name:	Tomt
Uniprot:	A1Y9I9
Entrez:	791260

Family

Belongs to:

class I-like SAM-binding methyltransferase superfamily

Alternative Names

Transmembrane O-methyltransferase homolog

Molecular Weight

Mass (kDA):
28.846 kDA

Genomic Context


Mouse

Location:	7 E2\|7
Sequence:	7;

Tissue Specificity

Widely expressed with high levels in outer and inner hair cells of the cochlea and vestibule.

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Tomt

References

PMID: 18953341 by Ahmed Z.M., et al. Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans.

PMID: 18794526 by Du X., et al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans.