Tumor protein p53-inducible nuclear protein 2 (TP53INP2)

Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing.

May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them into the autophagosome membrane by interacting with VMP1 where, in collaboration with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.