This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
UBE2C Antibodies
AND UBE2C ELISA kits, UBE2C Proteins
Many biological assays use antibodies to detect UBE2C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBE2C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBE2C antibodies...
Designing a Western blot for UBE2C? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the UBE2C Western Blot GuideUBE2C Infographic by Boster Bio
All UBE2C Products
Product
Figures
Specificity
Applications
Price
UBE2C Overview
Facts about Ubiquitin-conjugating enzyme E2 C.
Ubiquitin-conjugating enzyme E2 C (UBE2C)
Accepts ubiquitin from the E1 complicated and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination.
Acts as an important factor of the anaphase promoting complex/cyclosome (APC/C), a mobile cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating'Lys-11'-linked polyubiquitin chains on APC/C substrates, causing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
Gene Information
| Human | |
|---|---|
| Gene Name: | UBE2C |
| Uniprot: | O00762 |
| Entrez: | 11065 |
Family
| Belongs to: |
|---|
| ubiquitin-conjugating enzyme family |
Alternative Names
cyclin-selective ubiquitin carrier protein; dJ447F3.2; EC 6.3.2.19; UbcH10; UBCH10mitotic-specific ubiquitin-conjugating enzyme; UBE2C; Ubiquitin carrier protein C; ubiquitin carrier protein E2-C; ubiquitin-conjugating enzyme E2 C; ubiquitin-conjugating enzyme E2C; Ubiquitin-protein ligase C
Molecular Weight
Mass (kDA):
19.652 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.12 |
| Sequence: | 20; NC_000020.11 (45812576..45816957) |
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Carcinogenesis
- Adenocarcinoma
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
- Malignant Tumor Of Cervix
Pathways
- Cell Cycle
- Mitosis
- Cell Proliferation
- Proteolysis
- Anaphase
- Spindle Assembly
- Rna Interference
- Spindle Checkpoint
- Cell Growth
- Exit From Mitosis
- Spindle Assembly Checkpoint
- Pathogenesis
- Cell Division
PTMs
- Ubiquitination
- Methylation
Research Areas
- Cell Cycle and Replication
- Mitotic Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBE2C
bosterbio.com/bosterbio-gene-info-cards/UBE2C
References
PMID: 9122200 by Townsley F.M., et al. Dominant-negative cyclin-selective ubiquitin carrier protein E2- C/UbcH10 blocks cells in metaphase.
PMID: 15558010 by Rape M., et al. Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.