Ubr3 Antibodies

AND Ubr3 ELISA kits, Ubr3 Proteins

Many biological assays use antibodies to detect Ubr3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ubr3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ubr3 antibodies...

We validate the specificity of these antibodies to Ubr3 by testing them on tissues known to express Ubr3 positively and negatively. Browse below to find the Ubr3 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Ubr3 Infographic by Boster Bio

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Ubr3 Overview

Facts about E3 ubiquitin-protein ligase UBR3.

E3 ubiquitin-protein ligase UBR3 (Ubr3)

E3 ubiquitin-protein ligase that is a part of the N-end rule pathway (PubMed:17462990). Doesn't bind to proteins pose particular N-terminal residues that are destabilizing in line with the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed:17462990).

May play a role in Shh signaling by mediating the ubiquitination of Kif7 (PubMed:27195754). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed:27331610).

Gene Information

Mouse
Gene Name:	Ubr3
Uniprot:	Q5U430
Entrez:	68795

Family

Belongs to:

UBR1 family

Alternative Names

DKFZp434P117; E3 ubiquitin-protein ligase UBR3; EC 6.3.2.-; FLJ37422; KIAA2024DKFZp686N10185; MGC126489; N-recognin-3; ubiquitin protein ligase E3 component n-recognin 3 (putative); Ubiquitin-protein ligase E3-alpha-3; Ubiquitin-protein ligase E3-alpha-III; Zinc finger protein 650ZNF650

Molecular Weight

Mass (kDA):
212.757 kDA

Genomic Context


Mouse

Location:	2\|2 C2
Sequence:	2;

Tissue Specificity

Expressed in numerous cells of the smell, touch, vision, hearing and taste senses. Expressed in cells of the olfactory pathway, including the olfactory cell layer of the main olfactory epithelium (MOE), a mitral neuron cell layer of the olfactory bulb (OB), and a pyramidal cell layer of the piriform cortex of the olfactory cortex (OC). Expressed in the vomeronasal sensory epithelium of the vomeronasal organ (VNO) and the mitral cells of the accessory olfactory bulb. Expressed in tactile tissues, including the dorsal root ganglion, trigeminal ganglion and follicle-sinus complexes. Expressed in cells between hair follicle and sinus and also in the region of the rete ridge collar. Expressed in taste buds of the fungiform, circumvallate, and foliate papillae. Expressed in the spiral ganglion, the organ of Corti of the cochlea in the inner ear, in the sensory epithelium of macula and vestibular ganglion of the balancing system (at protein level). Expressed in the liver and skeletal muscle.

Diseases

Anosmia
Genomic Instability

Pathways

Dna Repair

PTMs

Reduction

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ubr3

References

PMID: 17462990 by Tasaki T., et al. Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems.

PMID: 27331610 by Li T., et al. The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals.