UGT1A3 Antibodies

AND UGT1A3 ELISA kits, UGT1A3 Proteins

Many biological assays use antibodies to detect UGT1A3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UGT1A3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UGT1A3 antibodies...

We validate the specificity of these antibodies to UGT1A3 by testing them on tissues known to express UGT1A3 positively and negatively. Browse below to find the UGT1A3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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UGT1A3 Infographic by Boster Bio

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UGT1A3 (NM_019093) Human Over-expression Lysate

Human

$960
Cat # LS054659
20 µg, 100 µg

UGT1A3 Overview

Facts about UDP-glucuronosyltransferase 1-3.

UGT1A3 3D structure. Source: alphafold

UDP-glucuronosyltransferase 1-3 (UGT1A3)

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Gene Information

Human
Gene Name:	UGT1A3
Uniprot:	P35503
Entrez:	54659

Family

Belongs to:

UDP-glycosyltransferase family

Alternative Names

GNT1; UDP glucuronosyltransferase 1 family, polypeptide A3; UDP glucuronosyltransferase 1A3; UDP glycosyltransferase 1 family, polypeptide A3; UDP-glucuronosyltransferase 1-3; UDP-glucuronosyltransferase 1A3; UDP-glucuronosyltransferase 1-C; UDPGT 1-3; UDPGT; UGT1; UGT1*3; UGT1.3; UGT1-03; UGT-1C; UGT1CEC 2.4.1.17

Molecular Weight

Mass (kDA):
60.338 kDA

Genomic Context


Human

Location:	2q37.1
Sequence:	2; NC_000002.12 (233729042..233773300)

Tissue Specificity

Isoform 1 and isoform 2 are expressed in liver, kidney, colon and small intestine. Isoform 1 but not isoform 2 is expressed in esophagus.

Subcellular Localizations

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.

Diseases

Malignant Neoplasms
Carcinoma
Liver Carcinoma
Cholestasis
Dysequilibrium Syndrome
Hyperbilirubinemia
Hepatotoxicity
Gilbert Disease (disorder)
Hiv Infections
Immunologic Deficiency Syndromes
Hepatitis
Liver Diseases
Liver Damage

Drug-induced Liver Injury
Malignant Neoplasm Of Breast
Diabetes Mellitus
Liver Neoplasms
Carcinogenesis
Cholangiocarcinoma
Neoplasms

Pathways

Conjugation
Excretion
Transport
Reverse Transcription
Cholesterol Homeostasis
Sulfation
Flavonoid Glucuronidation
Intestinal Absorption
Demethylation
Regeneration
Coagulation

Dna Modification
Acyl Glucuronidation
Response To Fenofibrate
Sos Response
Xenobiotic Glucuronidation

PTMs

Hydroxylation
Oxidation
Demethylation

Carboxylation
Phosphorylation
Glycosylation

Acetylation

Research Areas

Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UGT1A3

References

PMID: 1339448 by Ritter J.K., et al. A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.

PMID: 11434514 by Gong Q.H., et al. Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.