UDP-glucuronosyltransferase 1-4 (UGT1A4)

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate.

Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). .