UGT1A7 Antibodies

AND UGT1A7 ELISA kits, UGT1A7 Proteins

Many biological assays use antibodies to detect UGT1A7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UGT1A7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UGT1A7 antibodies...

We validate the specificity of these antibodies to UGT1A7 by testing them on tissues known to express UGT1A7 positively and negatively. Browse below to find the UGT1A7 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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UGT1A7 Infographic by Boster Bio

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UGT1A7 Overview

Facts about UDP-glucuronosyltransferase 1-7.

UGT1A7 3D structure. Source: alphafold

UDP-glucuronosyltransferase 1-7 (UGT1A7)

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Gene Information

Human
Gene Name:	UGT1A7
Uniprot:	Q9HAW7
Entrez:	54577

Family

Belongs to:

UDP-glycosyltransferase family

Alternative Names

GNT1; polypeptide A7; UDP glucuronosyltransferase 1 family, polypeptide A7; UDP-glucuronosyltransferase 1-7; UDP-glucuronosyltransferase 1-G; UDPGT 1-7; UGT1; UGT1-07; UGT1G

Molecular Weight

Mass (kDA):
59.819 kDA

Genomic Context


Human

Location:	2q37.1
Sequence:	2; NC_000002.12 (233681938..233773299)

Tissue Specificity

Liver and gastric tissue. Isoform 1 and isoform 2 are expressed in esophagus. Neither isoform is expressed in liver, kidney, colon and small intestine (PubMed:18004212).

Subcellular Localizations

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.

Diseases

Malignant Neoplasms
Carcinoma
Liver Carcinoma
Colorectal Cancer
Neoplasms
Carcinogenesis
Colorectal Neoplasms
Liver Neoplasms
Hepatitis
Dysequilibrium Syndrome
Hepatitis B
Hepatitis C
Gilbert Disease (disorder)

Adenocarcinoma
Liver Cirrhosis
Malignant Neoplasm Of Breast
Diarrhea
Malignant Squamous Cell Neoplasm
Malignant Head And Neck Neoplasm
Liver Diseases

Pathways

Conjugation
Excretion
Transport
Sulfation
Translation
Pathogenesis
Cell Proliferation
Flavonoid Glucuronidation
Protein Oxidation
Reverse Transcription

Dna Modification
Mrna Stabilization
Sos Response
Secretion

PTMs

Phosphorylation
Hydroxylation

Oxidation
Demethylation

Carboxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UGT1A7

References

PMID: 9271343 by Strassburg C.P., et al. Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue.

PMID: 11434514 by Gong Q.H., et al. Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.