Protein unc-13 homolog B Antibodies

AND UNC13B ELISA kits, Protein unc-13 homolog B Proteins

Many biological assays use antibodies to detect Protein unc-13 homolog B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein unc-13 homolog B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein unc-13 homolog B antibodies...

We validate the specificity of these antibodies to Protein unc-13 homolog B by testing them on tissues known to express UNC13B positively and negatively. Browse below to find the UNC13B antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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UNC13B Infographic by Boster Bio

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Anti-Protein unc-13 homolog B UNC13B Antibody

Western blot analysis of extracts of various cell lines, using UNC13B antibody at 1:1000 dilution

Immunofluorescence analysis of L929 cells using UNC13B antibody at dilution of 1:100

Immunohistochemistry of paraffin-embedded Human liver using UNC13B Rabbit pAb at dilution of 1:100

Human, Mouse

IF, IHC, ICC, WB

$405
Cat # A05240
100ul

UNC13B Overview

Facts about Protein unc-13 homolog B.

UNC13B 3D structure. Source: alphafold

Protein unc-13 homolog B (UNC13B)

Plays a role in vesicle maturation through exocytosis as a goal of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming before vesicle fusion and participates in the action - depending refilling of readily releasable vesicle pool (RRP).

Essential for synaptic vesicle maturation at a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). .

Gene Information

Human
Gene Name:	UNC13B
Uniprot:	O14795
Entrez:	10497

Family

Belongs to:

unc-13 family

Alternative Names

hmunc13; homolog of rat Munc13 (diacylglycerol-binding); MGC133279; MGC133280; MUNC13; munc13-2; MUNC13B; protein unc-13 homolog B; unc-13 homolog B (C. elegans); UNC13B; Unc13h2; unc-13-like (C. elegans); UNC13Unc13h2

Molecular Weight

Mass (kDA):
180.679 kDA

Genomic Context


Human

Location:	9p13.3
Sequence:	9; NC_000009.12 (35162009..35405338)

Tissue Specificity

Expressed in kidney cortical epithelial cells and brain.

Subcellular Localizations

Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Cell junction, synapse. Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity).

Diseases

Diabetic Nephropathy
Hyperglycemia
Lymphohistiocytosis, Hemophagocytic
Kidney Diseases
Histiocytosis, Non-langerhans-cell
Diabetes Mellitus
Familial Hemophagocytic Lymphocytosis
Sclerosis
Primary Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Parkinson Disease
Kidney Failure, Chronic

Complications Of Diabetes Mellitus
Diabetes Mellitus, Experimental
Diabetes Mellitus, Insulin-dependent
Swine Vesicular Disease
Tetanus
Insulinoma

Pathways

Exocytosis
Secretion
Synaptic Transmission
Localization
Synaptic Vesicle Priming
Vesicle Fusion
Pathogenesis
Snare Complex Assembly
Membrane Fusion
Transport
Reverse Transcription
Membrane Docking
Hormone Secretion

Secretory Pathway
Insulin Secretion
Vesicle Docking
Synaptic Vesicle Exocytosis
Cerebral Cortex Development
Neurogenesis
Protein Secretion

PTMs

Phosphorylation

Methylation

Research Areas

Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UNC13B

References

PMID: 9607201 by Song Y., et al. Cloning of a novel gene in the human kidney homologous to rat munc13s: its potential role in diabetic nephropathy.

PMID: 10233166 by Song Y., et al. Human munc13 is a diacylglycerol receptor that induces apoptosis and may contribute to renal cell injury in hyperglycemia.