Protein unc-80 homolog Antibodies

AND UNC80 ELISA kits, Protein unc-80 homolog Proteins

Many biological assays use antibodies to detect Protein unc-80 homolog, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein unc-80 homolog in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein unc-80 homolog antibodies...

We validate the specificity of these antibodies to Protein unc-80 homolog by testing them on tissues known to express UNC80 positively and negatively. Browse below to find the UNC80 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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UNC80 Infographic by Boster Bio

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UNC80 Overview

Facts about Protein unc-80 homolog.

Protein unc-80 homolog (UNC80)

Part of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that modulates neuronal excitability by controlling the dimensions of NALCN-dependent sodium-leak current.

UNC80 is vital for NALCN sensitivity to extracellular calcium. .

Gene Information

Human
Gene Name:	UNC80
Uniprot:	Q8N2C7
Entrez:	285175

Family

Belongs to:

unc-80 family

Alternative Names

C2orf21; FLJ14677; FLJ33496; FLJ53903; KIAA1843; protein unc-80 homolog; unc-80 homolog (C. elegans); UNC-80; WUGSC:H_NH0436C12.1

Molecular Weight

Mass (kDA):
363.39 kDA

Genomic Context


Human

Location:	2q34
Sequence:	2; NC_000002.12 (209771832..209999300)

Tissue Specificity

Moderately expressed in fetal brain, spinal cord, skeletal muscle, thymus, spleen, fetal liver, small intestine, colon, kidney and uterus. Highly expressed in adrenal gland, prostate and testis, as well as in brain and cerebellum.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UNC80

References

PMID: 26545877 by Perez Y., et al. UNC80 mutation causes a syndrome of hypotonia, severe intellectual disability, dyskinesia and dysmorphism, similar to that caused by mutations in its interacting cation channel NALCN.

PMID: 26708751 by Stray-Pedersen A., et al. Biallelic mutations in UNC80 cause persistent hypotonia, encephalopathy, growth retardation, and severe intellectual disability.