UROS Antibodies

AND UROS ELISA kits, UROS Proteins

Many biological assays use antibodies to detect UROS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UROS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UROS antibodies...

We validate the specificity of these antibodies to UROS by testing them on tissues known to express UROS positively and negatively. Browse below to find the UROS antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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UROS Infographic by Boster Bio

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UROS (NM_000375) Human Recombinant Protein

Coomassie blue staining of purified UROS protein

$1062
Cat # PROTP10746
20 µg

UROS Overview

Facts about Uroporphyrinogen-III synthase.

UROS 3D structure. Source: alphafold

Uroporphyrinogen-III synthase (UROS)

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways resulting in the broad diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform an assortment of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).

Gene Information

Human
Gene Name:	UROS
Uniprot:	P10746
Entrez:	7390

Family

Belongs to:

uroporphyrinogen-III synthase family

Alternative Names

EC 4.2.1.75; Hydroxymethylbilane hydrolyase [cyclizing]; hydroxymethylbilane hydrolyase; UROIIIS; uroporphyrinogen III synthase; Uroporphyrinogen-III cosynthase; uroporphyrinogen-III synthase

Molecular Weight

Mass (kDA):
28.628 kDA

Genomic Context


Human

Location:	10q26.2
Sequence:	10; NC_000010.11 (125784980..125823280, complement)

Tissue Specificity

Ubiquitous.

Diseases

Porphyria, Erythropoietic
Disorders Of Porphyrin Metabolism
Anemia
Anemia, Hemolytic
Hereditary Diseases
Bulla
Cicatrix
Sideroblastic Anemia
Inborn Errors Of Metabolism
Deficiency Of Uroporphyrinogen Iii Synthase
Acute Intermittent Porphyria
Hypoxia

Kidney Neoplasm
De Novo Mutation
Erythropoietic Protoporphyria
Carcinoma
Hemolysis (disorder)
Malignant Neoplasms

Pathways

Excretion
Localization
Mismatch Repair
Cell Death
Photosynthesis
Virulence

Rna Interference

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UROS

References

PMID: 3174619 by Tsai S.-F., et al. Human uroporphyrinogen III synthase: molecular cloning, nucleotide sequence, and expression of a full-length cDNA.

PMID: 11112350 by Aizencang G., et al. Human uroporphyrinogen-III synthase: genomic organization, alternative promoters, and erythroid-specific expression.