Ubiquitin carboxyl-terminal hydrolase 17 (USP17L2)

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the tiny GTPases NRAS and HRAS localization and activation.

In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome through the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis via deubiquitination of SUDS3 a regulator of histone deacetylation.