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- Table of Contents

Facts about Ubiquitin carboxyl-terminal hydrolase 17.
In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome through the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis via deubiquitination of SUDS3 a regulator of histone deacetylation.
| Human | |
|---|---|
| Gene Name: | USP17L2 |
| Uniprot: | Q6R6M4 |
| Entrez: | 377630 |

| Belongs to: |
|---|
| peptidase C19 family |

Deubiquitinating enzyme 17-like protein 2; Deubiquitinating protein 3; DUB-3; DUB3deubiquitinating enzyme 3; EC 3.1.2.15; EC 3.4.19.12; ubiquitin carboxyl-terminal hydrolase 17-like protein 2; ubiquitin specific peptidase 17-like 2; ubiquitin thioesterase 17-like protein 2; Ubiquitin thiolesterase 17-like protein 2; Ubiquitin-specific-processing protease 17-like protein 2
Mass (kDA):
59.619 kDA

| Human | |
|---|---|
| Location: | 8p23.1 |
| Sequence: | 8; NC_000008.11 (12137168..12138760, complement) |
Broadly expressed.
Nucleus. Endoplasmic reticulum.




PMID: 14699124 by Burrows J.F., et al. DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.
PMID: 15780755 by Burrows J.F., et al. The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.