Ubiquitin carboxyl-terminal hydrolase 22 (USP22)

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator.

Recruited to specific gene promoters by activators such as MYC, where it's required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.