USP51 Antibodies

AND USP51 ELISA kits, USP51 Proteins

Many biological assays use antibodies to detect USP51, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP51 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP51 antibodies...

We validate the specificity of these antibodies to USP51 by testing them on tissues known to express USP51 positively and negatively. Browse below to find the USP51 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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USP51 Infographic by Boster Bio

All USP51 Products

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Anti-USP51 Antibody (Center)

Fluorescent image of Hela cells stained with USP51 Antibody (Center)

USP51 Antibody (Center) western blot analysis in HepG2,MCF-7 cell line lysates (35ug/lane)

Human

IF, WB

$299
Cat # A13844-1
80 µl

USP51 (NM_201286) Human Over-expression Lysate

Human

$960
Cat # LS158880
20 µg, 100 µg

Anti-UBP51 USP51 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A13844
100ul

USP51 Overview

Facts about Ubiquitin carboxyl-terminal hydrolase 51.

USP51 3D structure. Source: alphafold

Ubiquitin carboxyl-terminal hydrolase 51 (USP51)

Specifically deubiquitinates'Lys-14' (H2AK13Ub) and'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1.

Exhibits also action for'Lys-27' or'Lys-63'-connected di-ubiquitin (PubMed:27083998). .

Gene Information

Human
Gene Name:	USP51
Uniprot:	Q70EK9
Entrez:	158880

Family

Belongs to:

peptidase C19 family

Alternative Names

Deubiquitinating enzyme 51; EC 3.1.2.15; EC 3.4.19.12; ubiquitin carboxyl-terminal hydrolase 51; ubiquitin specific peptidase 51; ubiquitin specific protease 51; ubiquitin thioesterase 51; Ubiquitin thiolesterase 51; Ubiquitin-specific-processing protease 51

Molecular Weight

Mass (kDA):
79.756 kDA

Genomic Context


Human

Location:	Xp11.21
Sequence:	X; NC_000023.11 (55484524..55489875, complement)

Tissue Specificity

Expressed in prostate, brain, lung, aorta and kidney.

Subcellular Localizations

Chromosome. Upon DNA damage, chromatin-bound USP51 disassociates from chromatin immediately following DNA damage and reassociates with chromatin following DNA repair.

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP51

References

PMID: 14715245 by Quesada V., et al. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.

PMID: 15060002 by Puente X.S., et al. A genomic analysis of rat proteases and protease inhibitors.