VAPB Antibodies

AND VAPB ELISA kits, VAPB Proteins

Many biological assays use antibodies to detect VAPB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with VAPB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop VAPB antibodies...

We validate the specificity of these antibodies to VAPB by testing them on tissues known to express VAPB positively and negatively. Browse below to find the VAPB antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for VAPB? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the VAPB Western Blot Guide

VAPB Infographic by Boster Bio

All VAPB Products

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Product

Figures

Specificity

Applications

Price

Anti-VAPB Antibody Picoband®

Western blot analysis of VAPB using anti-VAPB antibody (A01372)

IHC analysis of VAPB using anti-VAPB antibody (A01372)

Human, Mouse

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A01372
100 μg/vial

VAPB (NM_004738) Human Over-expression Lysate

Human

$628
Cat # LS009217
20 µg, 100 µg

Human VAP-B Recombinant Protein

SDS-PAGE

$250
Cat # PROTO95292
Starting from 20ug

VAPB Overview

Facts about Vesicle-associated membrane protein-associated protein B/C.

VAPB 3D structure. Source: alphafold

Vesicle-associated membrane protein-associated protein B/C (VAPB)

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.

Gene Information

Human
Gene Name:	VAPB
Uniprot:	O95292
Entrez:	9217

Family

Belongs to:

VAMP-associated protein (VAP) (TC 9.B.17) family

Alternative Names

ALS8; ALS8VAMP-B/VAMP-C; VAMP (vesicle-associated membrane protein)-associated protein B and C; VAMP-associated 33 kDa protein; VAMP-associated protein B/C; VAMP-B; VAMP-C; VAPB; VAP-B; VAP-B/VAP-C; VAPC; VAP-C; vesicle-associated membrane protein-associated protein B/C

Molecular Weight

Mass (kDA):
27.228 kDA

Genomic Context


Human

Location:	20q13.32
Sequence:	20; NC_000020.11 (58389211..58451101)

Tissue Specificity

Ubiquitous. Isoform 1 predominates.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane.

Diseases

Amyotrophic Lateral Sclerosis
Sclerosis
Primary Lateral Sclerosis
Motor Neuron Disease
Actinomycetales Infections
Nerve Degeneration
Neurodegenerative Disorders
Spinal Muscular Atrophy
Atrophy
Feline Urological Syndrome
Muscular Atrophy
Pneumonia
Hepatitis

Horse Diseases
Hepatitis C
Dementia
Swine Diseases
Malignant Neoplasms
Neoplasms
Protrusion

Interacting Proteins

EMD
Epha4
RMDN2
VAPA
YIF1A

ZFYVE27

Pathways

Virulence
Pathogenesis
Transport
Localization
Translation
Cell Death
Lipid Transport
Cell Growth
Tropism
Lactation
Rna Processing
Cell Adhesion
Osteoclast Differentiation

Cellular Homeostasis
Proteolysis
Mitochondrial Transport
Reverse Transcription
Phagocytosis
Membrane Docking
Intracellular Transport

PTMs

Cleavage
Phosphorylation

Reduction
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VAPB

References

PMID: 9920726 by Nishimura Y., et al. Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins.

PMID: 16227268 by Hamamoto I., et al. Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B.