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- Table of Contents
VHL Antibodies
AND VHL ELISA kits, VHL Proteins
Many biological assays use antibodies to detect VHL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with VHL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop VHL antibodies...
Designing a Western blot for VHL? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the VHL Western Blot GuideVHL Infographic by Boster Bio
All VHL Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00079-3
100 μg/vial
Cat # A00079-3
100 μg/vial
Human
$628
Cat # LS007428
20 µg, 100 µg
Cat # LS007428
20 µg, 100 µg
Human
ELISA
$540
Cat # EKC2313
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2313
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2185
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2185
1 kit, containing two 96-well plates and all necessary reagents
VHL Overview
Facts about von Hippel-Lindau disease tumor suppressor.
von Hippel-Lindau disease tumor suppressor (VHL)
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to work as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions.
Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive Fashion, ADRB2.
Gene Information
| Human | |
|---|---|
| Gene Name: | VHL |
| Uniprot: | P40337 |
| Entrez: | 7428 |
Family
| Belongs to: |
|---|
| VHL family |
Alternative Names
elongin binding protein; HRCA1; Protein G7; pVHL; RCA1; VHL; VHL1; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome; von Hippel-Lindau tumor suppressor
Molecular Weight
Mass (kDA):
24.153 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p25.3 |
| Sequence: | 3; NC_000003.12 (10141778..10153667) |
Tissue Specificity
Expressed in the adult and fetal brain and kidney.
Subcellular Localizations
[Isoform 1]: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane.; [Isoform 3]: Cytoplasm. Nucleus. Equally distributed between the nucleus and the cytoplasm but not membrane-associated.
Diseases
- Von Hippel-lindau Syndrome
- Neoplasms
- Carcinoma
- Renal Cell Carcinoma
- Malignant Neoplasms
- Kidney Neoplasm
- Hypoxia
- Pheochromocytoma
- Hemangioblastoma
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Kidney
- Adrenal Gland Neoplasms
- Tumor Angiogenesis
Interacting Proteins
- CUL2
- DGKI
- FN1
- FZR1
- GLI1
- HIF1A
- Hif1a
- HNRNPL
- HSF2BP
- MDFI
Pathways
- Angiogenesis
- Pathogenesis
- Methylation
- Cell Proliferation
- Localization
- Cell Cycle
- Cell Growth
- Proteolysis
- Oncogenesis
- Response To Hypoxia
- Oxygen Homeostasis
- Cell Death
- Dna Methylation
PTMs
- Methylation
- Ubiquitination
- Hydroxylation
- Phosphorylation
- Cleavage
- Acetylation
- Sumoylation
- Glycosylation
Research Areas
- Apoptosis
- Cancer
- HIF Target Genes
- Hypoxia
- Neuronal Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VHL
bosterbio.com/bosterbio-gene-info-cards/VHL
References
PMID: 8493574 by Latif F., et al. Identification of the von Hippel-Lindau disease tumor suppressor gene.
PMID: 8733131 by Richards F.M., et al. Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesis.