WASH complex subunit 2A (WASHC2A)

Acts at least in part as part of this WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that function as transport intermediates through endosome sorting. Mediates the recruitment of this WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC.

Mediates the recruitment of this F-actin-capping protein dimer into the WASH core complex probably promoting localized F-actin polymerization required for vesicle scission. Involved from the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1.