WASH complex subunit 2C Antibodies

AND WASHC2C ELISA kits, WASH complex subunit 2C Proteins

Many biological assays use antibodies to detect WASH complex subunit 2C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WASH complex subunit 2C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WASH complex subunit 2C antibodies...

We validate the specificity of these antibodies to WASH complex subunit 2C by testing them on tissues known to express WASHC2C positively and negatively. Browse below to find the WASHC2C antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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WASHC2C Infographic by Boster Bio

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FAM21C (WASHC2C) (NM_001169107) Human Recombinant Protein

Coomassie blue staining of purified WASHC2C protein

$1062
Cat # PROTQ9Y4E1
20 µg

WASHC2C Overview

Facts about WASH complex subunit 2C.

WASHC2C 3D structure. Source: alphafold

WASH complex subunit 2C (WASHC2C)

Acts at least in part as part of this WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates through endosome sorting. Mediates the recruitment of this WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC.

Mediates the recruitment of this F-actin-capping protein dimer into the WASH core complex probably boosting localized F-actin polymerization needed for vesicle scission (PubMed:19922874, PubMed:20498093, PubMed:22513087, PubMed:23331060). Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4- phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns- (5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2).

Gene Information

Human
Gene Name:	WASHC2C
Uniprot:	Q9Y4E1
Entrez:	253725

Family

Belongs to:

FAM21 family

Alternative Names

WASH complex subunit 2C

Molecular Weight

Mass (kDA):
144.911 kDA

Genomic Context


Human

Location:	10q11.22
Sequence:	10; NC_000010.11 (45727043..45792964)

Subcellular Localizations

Early endosome membrane. Cell membrane. Partially colocalizes with RAB11A, a recycling endosome marker. Associates with lipid raft microdomains on the plasma membrane.

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WASHC2C

References

PMID: 18550675 by Huang C.Y., et al. A novel cellular protein, VPEF, facilitates vaccinia virus penetration into HeLa cells through fluid phase endocytosis.

PMID: 19922874 by Gomez T.S., et al. A FAM21-containing WASH complex regulates retromer-dependent sorting.