WASH complex subunit 5 Antibodies

AND WASHC5 ELISA kits, WASH complex subunit 5 Proteins

Many biological assays use antibodies to detect WASH complex subunit 5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WASH complex subunit 5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WASH complex subunit 5 antibodies...

We validate the specificity of these antibodies to WASH complex subunit 5 by testing them on tissues known to express WASHC5 positively and negatively. Browse below to find the WASHC5 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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WASHC5 Infographic by Boster Bio

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WASHC5 Overview

Facts about WASH complex subunit 5.

WASHC5 3D structure. Source: alphafold

WASH complex subunit 5 (WASHC5)

Acts at least in part as part of the WASH core complex whose assembly at the surface of endosomes appears to inhibit WASH nucleation-promoting factor (NPF) action in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). May be involved in axonal outgrowth.

Involved in cellular localization of ADRB2 (PubMed:23085491). Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (PubMed:23676666).

Gene Information

Human
Gene Name:	WASHC5
Uniprot:	Q12768
Entrez:	9897

Family

Belongs to:

strumpellin family

Alternative Names

WASH complex subunit 5

Molecular Weight

Mass (kDA):
134.286 kDA

Genomic Context


Human

Location:	8q24.13
Sequence:	8; NC_000008.11 (125024260..125091819, complement)

Tissue Specificity

Expressed ubiquitously.

Subcellular Localizations

Cytoplasm, cytosol. Endoplasmic reticulum. Early endosome. Colocalizes with SYP/synaptophysin in the external molecular layer of the dentate gyrus and in motoneurons of the ventral horn of spinal cord.

Interacting Proteins

SNX1

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WASHC5

References

PMID: 19922875 by Derivery E., et al. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.

PMID: 20833645 by Clemen C.S., et al. Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases.