WDR41 Antibodies

AND WDR41 ELISA kits, WDR41 Proteins

Many biological assays use antibodies to detect WDR41, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WDR41 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WDR41 antibodies...

We validate the specificity of these antibodies to WDR41 by testing them on tissues known to express WDR41 positively and negatively. Browse below to find the WDR41 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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WDR41 Infographic by Boster Bio

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WDR41 (NM_018268) Human Over-expression Lysate

Human

$628
Cat # LS055255
20 µg, 100 µg

WDR41 Overview

Facts about WD repeat-containing protein 41.

WDR41 3D structure. Source: alphafold

WD repeat-containing protein 41 (WDR41)

Non-catalytic part of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their busy GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069).

The C9orf72- SMCR8 complex also serves as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292). .

Gene Information

Human
Gene Name:	WDR41
Uniprot:	Q9HAD4
Entrez:	55255

Family

Belongs to:

No superfamily

Alternative Names

FLJ10904; WD repeat domain 41; WD repeat-containing protein 41

Molecular Weight

Mass (kDA):
51.728 kDA

Genomic Context


Human

Location:	5q13.3-q14.1
Sequence:	5; NC_000005.10 (77426652..77620611, complement)

Subcellular Localizations

Cytoplasm.

Diseases

Mental Disorders
Mood Disorders
Alzheimer's Disease
Bipolar Disorder

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WDR41

References

PMID: 27193190 by Sullivan P.M., et al. The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.

PMID: 27103069 by Sellier C., et al. Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.