WDR59 Antibodies

AND WDR59 ELISA kits, WDR59 Proteins

Many biological assays use antibodies to detect WDR59, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WDR59 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WDR59 antibodies...

We validate the specificity of these antibodies to WDR59 by testing them on tissues known to express WDR59 positively and negatively. Browse below to find the WDR59 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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WDR59 Infographic by Boster Bio

All WDR59 Products

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WDR59 (NM_030581) Human Recombinant Protein

Coomassie blue staining of purified WDR59 protein

$1062
Cat # PROTQ6PJI9
20 µg

WDR59 (NM_030581) Human Over-expression Lysate

Human

$960
Cat # LS079726
20 µg, 100 µg

WDR59 Overview

Facts about GATOR complex protein WDR59.

WDR59 3D structure. Source: alphafold

GATOR complex protein WDR59 (WDR59)

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238).

It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). .

Gene Information

Human
Gene Name:	WDR59
Uniprot:	Q6PJI9
Entrez:	79726

Family

Belongs to:

WD repeat WDR59 family

Alternative Names

FLJ12270; KIAA1923; MGC11230; WD repeat domain 59; WD repeat-containing protein 59

Molecular Weight

Mass (kDA):
109.793 kDA

Genomic Context


Human

Location:	16q23.1
Sequence:	16; NC_000016.10 (74871362..74985146, complement)

Subcellular Localizations

Lysosome membrane.

Interacting Proteins

WDR24

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WDR59

References

PMID: 25263562 by Chantranupong L., et al. The Sestrins interact with GATOR2 to negatively regulate the amino- acid-sensing pathway upstream of mTORC1.

PMID: 25457612 by Parmigiani A., et al. Sestrins inhibit mTORC1 kinase activation through the GATOR complex.