WDR81 Antibodies

AND WDR81 ELISA kits, WDR81 Proteins

Many biological assays use antibodies to detect WDR81, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WDR81 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WDR81 antibodies...

We validate the specificity of these antibodies to WDR81 by testing them on tissues known to express WDR81 positively and negatively. Browse below to find the WDR81 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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WDR81 Infographic by Boster Bio

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WDR81 Overview

Facts about WD repeat-containing protein 81.

WDR81 3D structure. Source: alphafold

WD repeat-containing protein 81 (WDR81)

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes through BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 material of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301).

It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a part in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates.

Gene Information

Human
Gene Name:	WDR81
Uniprot:	Q562E7
Entrez:	124997

Family

Belongs to:

WD repeat WDR81 family

Alternative Names

WD repeat-containing protein 81

Molecular Weight

Mass (kDA):
211.697 kDA

Genomic Context


Human

Location:	17p13.3
Sequence:	17; NC_000017.11 (1716523..1738599)

Tissue Specificity

Widely expressed. In the brain, highest levels in cerebellum and corpus callosum.

Subcellular Localizations

Early endosome membrane; Peripheral membrane protein. Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle, autophagosome membrane. Mitochondrion. Cytoplasm, cytosol.

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WDR81

References

PMID: 26783301 by Liu K., et al. Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.

PMID: 27126989 by Rapiteanu R., et al. A genetic screen identifies a critical role for the WDR81-WDR91 complex in the trafficking and degradation of tetherin.