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- Table of Contents

Facts about Werner syndrome ATP-dependent helicase.
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| Human | |
|---|---|
| Gene Name: | WRN |
| Uniprot: | Q14191 |
| Entrez: | 7486 |

| Belongs to: |
|---|
| helicase family |

DKFZp686C2056; DNA helicase, RecQ-like type 3; EC 3.1; EC 3.6.1; EC 3.6.4.12; Exonuclease WRN; RecQ protein-like 2; RecQ3; RECQ3RECQL3; RECQL2Werner syndrome ATP-dependent helicase; Werner syndrome; Werner syndrome, RecQ helicase-like
Mass (kDA):
162.461 kDA

| Human | |
|---|---|
| Location: | 8p12 |
| Sequence: | 8; NC_000008.11 (31033749..31176138) |
Nucleus, nucleolus. Nucleus. Nucleus, nucleoplasm. Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation.






PMID: 8602509 by Yu C.-E., et al. Positional cloning of the Werner's syndrome gene.
PMID: 16723399 by Agrelo R., et al. Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.