WDR4 Antibodies

AND WDR4 ELISA kits, WDR4 Proteins

Many biological assays use antibodies to detect WDR4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WDR4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WDR4 antibodies...

We validate the specificity of these antibodies to WDR4 by testing them on tissues known to express WDR4 positively and negatively. Browse below to find the WDR4 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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WDR4 Infographic by Boster Bio

All WDR4 Products

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Applications

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Anti-WDR4 Mouse Monoclonal Antibody [Clone ID: OTI4G1]

Western blot analysis of WDR4 using anti-WDR4 antibody (M10150)

HEK293T cells transfected with either WDR4 (Myc-DDK-tagged) overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-WDR4 antibody (M10150)

Anti-WDR4 mouse monoclonal antibody (M10150) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY WDR4

Human

Flow Cytometry, IF, WB

$523
Cat # M10150
100 µl

Anti-WDR4 Rabbit Monoclonal Antibody

Western blot analysis of WDR4 using anti-WDR4 antibody (M10150-1)

Immunofluorescent analysis using the Antibody at 1:50 dilution

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M10150-1
100 μl/vial

WDR4 (NM_033661) Human Over-expression Lysate

Human

$628
Cat # LS010785
20 µg, 100 µg

WDR4 Overview

Facts about tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4.

WDR4 3D structure. Source: alphafold

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (WDR4)

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is necessary to stabilize and induce conformational changes of the catalytic subunit.

Gene Information

Human
Gene Name:	WDR4
Uniprot:	P57081
Entrez:	10785

Family

Belongs to:

WD repeat TRM82 family

Alternative Names

tRNA (guanine-N(7)-)-methyltransferase subunit WDR4; WD repeat domain 4, 10TRM82; WD repeat-containing protein 4

Molecular Weight

Mass (kDA):
45.49 kDA

Genomic Context


Human

Location:	21q22.3
Sequence:	21; NC_000021.9 (42843075..42891695, complement)

Subcellular Localizations

Nucleus. Chromosome. Localizes at the site of nascent DNA synthesis.

Diseases

Down Syndrome
Complete Hearing Loss
Anxiety Disorders
Hereditary Diseases
Trisomy
Bipolar Disorder

Psychotic Disorders

Interacting Proteins

FAM118A
FEN1
METTL1
RABGGTB

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WDR4

References

PMID: 10950928 by Michaud J., et al. Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein.

PMID: 12403464 by Alexandrov A., et al. Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.