Xylosyltransferase 1 Antibodies

AND XYLT1 ELISA kits, Xylosyltransferase 1 Proteins

Many biological assays use antibodies to detect Xylosyltransferase 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Xylosyltransferase 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Xylosyltransferase 1 antibodies...

We validate the specificity of these antibodies to Xylosyltransferase 1 by testing them on tissues known to express XYLT1 positively and negatively. Browse below to find the XYLT1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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XYLT1 Infographic by Boster Bio

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XYLT1 (NM_022166) Human Over-expression Lysate

Human

$960
Cat # LS064131
20 µg, 100 µg

XYLT1 Overview

Facts about Xylosyltransferase 1.

XYLT1 3D structure. Source: alphafold

Xylosyltransferase 1 (XYLT1)

Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (PubMed:15461586, PubMed:17189265, PubMed:24581741, PubMed:23982343).

Required for normal embryonic and postnatal skeleton development, especially of the long bones (PubMed:24581741, PubMed:23982343). Required for normal maturation of chondrocytes during bone development, and regular onset of ossification (By similarity).

Gene Information

Human
Gene Name:	XYLT1
Uniprot:	Q86Y38
Entrez:	64131

Family

Belongs to:

glycosyltransferase 14 family

Alternative Names

Xylosyltransferase 1

Molecular Weight

Mass (kDA):
107.569 kDA

Genomic Context


Human

Location:	16p12.3
Sequence:	16; NC_000016.10 (17101769..17470960, complement)

Tissue Specificity

Widely expressed. Expressed at higher level in placenta, kidney and pancreas. Weakly expressed in skeletal muscle.

Subcellular Localizations

Golgi apparatus membrane; Single-pass type II membrane protein. Secreted. Detected predominantly in the Golgi apparatus.

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/XYLT1

References

PMID: 15461586 by Mueller S., et al. Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity.

PMID: 11099377 by Goetting C., et al. Molecular cloning and expression of human UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase and its first isoform XT-II.