Exportin-T (XPOT)

Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and into the GTPase Ran in its active GTP- bound form.

Docking of the trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complicated and hydrolysis of Ran-GTP into Ran-GDP (triggered by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor.