3'-5' RNA helicase YTHDC2 Antibodies

AND YTHDC2 ELISA kits, 3'-5' RNA helicase YTHDC2 Proteins

Many biological assays use antibodies to detect 3'-5' RNA helicase YTHDC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with 3'-5' RNA helicase YTHDC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop 3'-5' RNA helicase YTHDC2 antibodies...

We validate the specificity of these antibodies to 3'-5' RNA helicase YTHDC2 by testing them on tissues known to express YTHDC2 positively and negatively. Browse below to find the YTHDC2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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YTHDC2 Infographic by Boster Bio

All YTHDC2 Products

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Anti-3'-5' RNA helicase YTHDC2 YTHDC2 Antibody

Western blot analysis of extracts of various cell lines, using YTHDC2 Rabbit pAb at 1:3000 dilution

Human, Mouse, Rat

$405
Cat # A09692
100ul

Anti-YTHDC2 Antibody Picoband®

Western blot analysis of YTHDC2 using anti-YTHDC2 antibody (A09692-1)

IF analysis of YTHDC2 using anti-YTHDC2 antibody (A09692-1)

Flow Cytometry analysis of MCF-7 cells using anti-YTHDC2 antibody (A09692-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A09692-1
100 μg/vial

YTHDC2 (NM_022828) Human Over-expression Lysate

Human

$960
Cat # LS064848
20 µg, 100 µg

YTHDC2 Overview

Facts about 3'-5' RNA helicase YTHDC2.

YTHDC2 3D structure. Source: alphafold

3'-5' RNA helicase YTHDC2 (YTHDC2)

3'-5' RNA helicase that plays an integral role in the female and male germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321). Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs, a modification present at internal sites of mRNAs and a few non-coding RNAs that plays a role in the efficacy of RNA processing and stability (PubMed:26318451, PubMed:29033321).

Essential for ensuring a successful development of the meiotic program from the germline by regulating the amount of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321).

Gene Information

Human
Gene Name:	YTHDC2
Uniprot:	Q9H6S0
Entrez:	64848

Family

Belongs to:

DEAD box helicase family

Alternative Names

YTH domain containing 2

Molecular Weight

Mass (kDA):
160.248 kDA

Genomic Context


Human

Location:	5q22.2
Sequence:	5; NC_000005.10 (113513683..113595284)

Tissue Specificity

Expressed in testis (PubMed:29087293). Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis (PubMed:29087293).

Subcellular Localizations

Cytoplasm.

Interacting Proteins

IRF4
Meioc

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/YTHDC2

References

PMID: 26318451 by Xu C., et al. structural basis for the discriminative recognition of N6- methyladenosine RNA by the human YT521-B homology domain family of proteins.

PMID: 29033321 by Wojtas M.N., et al. Regulation of m6A transcripts by the 3'-5' RNA helicase YTHDC2 is essential for a successful meiotic program in the mammalian germline.