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- Table of Contents
3'-5' RNA helicase YTHDC2 Antibodies
AND YTHDC2 ELISA kits, 3'-5' RNA helicase YTHDC2 Proteins
Many biological assays use antibodies to detect 3'-5' RNA helicase YTHDC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with 3'-5' RNA helicase YTHDC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop 3'-5' RNA helicase YTHDC2 antibodies...
Designing a Western blot for 3'-5' RNA helicase YTHDC2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the YTHDC2 Western Blot GuideYTHDC2 Infographic by Boster Bio
All YTHDC2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A09692-1
100 μg/vial
Cat # A09692-1
100 μg/vial
YTHDC2 Overview
Facts about 3'-5' RNA helicase YTHDC2.
3'-5' RNA helicase YTHDC2 (YTHDC2)
3'-5' RNA helicase that plays an integral role in the female and male germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321). Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs, a modification present at internal sites of mRNAs and a few non-coding RNAs that plays a role in the efficacy of RNA processing and stability (PubMed:26318451, PubMed:29033321).
Essential for ensuring a successful development of the meiotic program from the germline by regulating the amount of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321).
Gene Information
| Human | |
|---|---|
| Gene Name: | YTHDC2 |
| Uniprot: | Q9H6S0 |
| Entrez: | 64848 |
Family
| Belongs to: |
|---|
| DEAD box helicase family |
Alternative Names
YTH domain containing 2
Molecular Weight
Mass (kDA):
160.248 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q22.2 |
| Sequence: | 5; NC_000005.10 (113513683..113595284) |
Tissue Specificity
Expressed in testis (PubMed:29087293). Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis (PubMed:29087293).
Subcellular Localizations
Cytoplasm.
Interacting Proteins
- IRF4
- Meioc
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/YTHDC2
bosterbio.com/bosterbio-gene-info-cards/YTHDC2
References
PMID: 26318451 by Xu C., et al. structural basis for the discriminative recognition of N6- methyladenosine RNA by the human YT521-B homology domain family of proteins.
PMID: 29033321 by Wojtas M.N., et al. Regulation of m6A transcripts by the 3'-5' RNA helicase YTHDC2 is essential for a successful meiotic program in the mammalian germline.