- Table of Content
Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
|Sequence:||2; NC_000002.12 (9583967..9630997, complement)|
Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
Cytoplasm. In neurons, axonally transported to the nerve terminals.