Probable palmitoyltransferase ZDHHC21 (Zdhhc21)

Palmitoylates sex steroid hormone receptors, such as ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This impacts rapid intracellular signaling by sex hormones through ERK and AKT kinases as well as the generation of cAMP, but doesn't affect that mediated by their nuclear receptor (By similarity).

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