ZFHX3 Antibodies

AND ZFHX3 ELISA kits, ZFHX3 Proteins

Many biological assays use antibodies to detect ZFHX3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ZFHX3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ZFHX3 antibodies...

We validate the specificity of these antibodies to ZFHX3 by testing them on tissues known to express ZFHX3 positively and negatively. Browse below to find the ZFHX3 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ZFHX3 Infographic by Boster Bio

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ZFHX3 Overview

Facts about Zinc finger homeobox protein 3.

Zinc finger homeobox protein 3 (ZFHX3)

Transcriptional regulator which can function as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence.

In concert with SMAD- dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms through transcriptional activation of neuropeptidergic genes that are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity).

Gene Information

Human
Gene Name:	ZFHX3
Uniprot:	Q15911
Entrez:	463

Family

Belongs to:

No superfamily

Alternative Names

Zinc finger homeobox protein 3

Molecular Weight

Mass (kDA):
404.419 kDA

Genomic Context


Human

Location:	16q22.2-q22.3
Sequence:	16; NC_000016.10 (72782885..73891931, complement)

Tissue Specificity

Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level). Expression is higher in ER-positive breast tumors than ER-negative breast tumors (at protein level).

Subcellular Localizations

Nucleus. Cytoplasm. Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. Expressed in nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body.

Interacting Proteins

KRT40

PTMs

Isopeptide bond

Phosphoprotein

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZFHX3

References

PMID: 7592926 by Miura Y., et al. Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner.

PMID: 1719379 by Morinaga T., et al. A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers.