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- Table of Contents
ZFP36L2 Antibodies
AND ZFP36L2 ELISA kits, ZFP36L2 Proteins
Many biological assays use antibodies to detect ZFP36L2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ZFP36L2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ZFP36L2 antibodies...
Designing a Western blot for ZFP36L2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ZFP36L2 Western Blot GuideDesigning an IHC experiment for ZFP36L2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ZFP36L2 IHC GuideZFP36L2 Infographic by Boster Bio
All ZFP36L2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1726
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1726
1 kit, containing one 96-well plate and all necessary reagents
ZFP36L2 Overview
Facts about mRNA decay activator protein ZFP36L2.
mRNA decay activator protein ZFP36L2 (ZFP36L2)
Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by boosting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to convey signaling events to the mRNA decay machinery (PubMed:25106868).
Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Promotes ARE- containing mRNA decay of this low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13- acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868).
Gene Information
| Human | |
|---|---|
| Gene Name: | ZFP36L2 |
| Uniprot: | P47974 |
| Entrez: | 678 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
HF.10; HF10Zinc finger protein HF.10; Zfp105; zinc finger protein 35 (clone HF.10); zinc finger protein 35
Molecular Weight
Mass (kDA):
51.063 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p21 |
| Sequence: | 2; NC_000002.12 (43222402..43226606, complement) |
Tissue Specificity
Expressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (at protein level) (PubMed:27182009).
Subcellular Localizations
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner.
Diseases
- Inflammation
- Infertility
- Female Infertility
- Leukemia
- Leukemia, Myelocytic, Acute
- Neoplasms
- Myeloid Leukemia
- Monosomy
- Burkitt Lymphoma
- Adult Acute Myeloblastic Leukemia
- Flt3 Internal Tandem Duplication
- Pancytopenia
Pathways
- Localization
- S Phase
- Cell Migration
- Cell Proliferation
- Regulation Of Macrophage Activation
- Regulation Of Gene Expression
- Nuclear Export
- Macrophage Activation
- Response To Oxidative Stress
- Sensitization
- Translation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZFP36L2
bosterbio.com/bosterbio-gene-info-cards/ZFP36L2
References
PMID: 8545129 by Ino T., et al. Identification of a member of the TIS11 early response gene family at the insertion point of a DNA fragment containing a gene for the T-cell receptor beta chain in an acute T-cell leukemia.
PMID: 7835719 by Nie X.F., et al. ERF-2, the human homologue of the murine Tis11d early response gene.