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- Table of Contents
Facts about Zinc finger protein 268.
Plays a role during prostate cancer development and progression. .
Human | |
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Gene Name: | ZNF268 |
Uniprot: | Q14587 |
Entrez: | 10795 |
Belongs to: |
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krueppel C2H2-type zinc-finger protein family |
zinc finger protein 446; Zinc finger protein with KRAB and SCAN domains 20; ZKSCAN20FLJ20626; ZSCAN30
Mass (kDA):
108.374 kDA
Human | |
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Location: | 12q24.33 |
Sequence: | 12; NC_000012.12 (133181495..133214832) |
Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform 1 is expressed in pancreas, lung, skeletal muscle, heart, placenta, liver, kidney and brain. Isoform 2 expressed in chronic lymphocytic leukemia (CLL) and several tumor cell lines. Isoform 3 is expressed in several tumor cells. Isoform 5 is expressed in fetal liver and several tumor cells. Isoform 6 is weakly expressed in brain, lung amd small intestin and in several tumor cells. Isoform 7 is expressed in fetal liver and several tumor cells.
[Isoform 1]: Nucleus.; [Isoform 2]: Nucleus. Cytoplasm.
PMID: 11311945 by Gou D.M., et al. Cloning and characterization of a novel Kruppel-like zinc finger gene, ZNF268, expressed in early human embryo.
PMID: 12200376 by Krackhardt A.M., et al. Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX.