Zinc finger protein 304 Antibodies

AND ZNF304 ELISA kits, Zinc finger protein 304 Proteins

Many biological assays use antibodies to detect Zinc finger protein 304, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc finger protein 304 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc finger protein 304 antibodies...

We validate the specificity of these antibodies to Zinc finger protein 304 by testing them on tissues known to express ZNF304 positively and negatively. Browse below to find the ZNF304 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ZNF304 Overview

Facts about Zinc finger protein 304.

ZNF304 3D structure. Source: alphafold

Zinc finger protein 304 (ZNF304)

Acts as transcriptional regulator and plays a role in gene silencing (PubMed:24623306, PubMed:26081979). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306).

Also required to keep a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of'Lys-27' of histone H3 (H3K27me3) (PubMed:24623306) in a Polycomb group (PcG) complexes-dependent method. Associates in promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes in those sites (PubMed:24623306).

Gene Information

Human
Gene Name:	ZNF304
Uniprot:	Q9HCX3
Entrez:	57343

Family

Belongs to:

krueppel C2H2-type zinc-finger protein family

Alternative Names

ZNF304 zinc finger protein 304

Molecular Weight

Mass (kDA):
75.047 kDA

Genomic Context


Human

Location:	19q13.43
Sequence:	19; NC_000019.10 (57351253..57359898)

Tissue Specificity

Expressed in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Expressed strongly in colorectal cancers cells (CRCs) (PubMed:24623306). Expressed strongly in ovarian carcinoma (OC) tumor cell lines compared to non- transformed ovarian epithelial cells (at protein level) (PubMed:26081979). Expressed in lymphoid tissues, thyroid, adrenal gland, prostate, pancreas and skeletal muscles (PubMed:12051768).

Subcellular Localizations

Nucleus. Associates with chromatin (PubMed:24623306).

Pathways

Regulation Of Lymphocyte Activation
Lymphocyte Activation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZNF304

References

PMID: 12051768 by Sabater L., et al. Identification of a KRAB-containing zinc finger protein, ZNF304, by AU-motif-directed display method and initial characterization in lymphocyte activation.

PMID: 24623306 by Serra R.W., et al. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.