Zinc finger protein 568 (ZNF568)

Has transcriptional repression activity, partly through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early growth and regulates convergent extension movements necessary for axis elongation and tissue morphogenesis in all germ layers.

Also vital for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.