Tissue-resident T-cell transcription regulator protein ZNF683 (ZNF683)

Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types like tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins which promote the egress of tissue-resident T-cell inhabitants from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, like the skin and gut, but also in other nonbarrier tissues like liver and liver, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection.

Plays also a role in the differentiation of both thymic and peripheral NKT cells. Negatively regulates the accumulation of interferon-gamma (IFN- gamma) in NKT cells at steady state or after antigenic stimulation.